Organotypically cultured skin tissue comprising NIKS cells...

Details Organotypically cultured skin tissue comprising NIKS cells... Organotypically cultured skin tissue comprising NIKS cells...

2004-05-19

2010-10-05

Angell, J. E (Department: 1635)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S371000

Reexamination Certificate

active

07807148

ABSTRACT:
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.

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