Organosilicon compounds and antitumor agents containing the comp

Details Organosilicon compounds and antitumor agents containing the comp Organosilicon compounds and antitumor agents containing the comp

1983-10-17

1985-12-24

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

546 14, 549 4, 549214, 556410, 556419, 556427, A61K 31695, C07F 710

Patent

active

045606790

ABSTRACT:
A novel organosilicon compound represented by a formula ##STR1## wherein A is methylene, carbonyl or sulfonyl group; R, R.sub.1 and R.sub.2 are alkyl group, respectively; R.sub.3 is alkyl, substituted alkyl, alkenyl, phenyl, substituted phenyl, naphthyl, substituted naphthyl, pyridyl, substituted pyridyl, furyl, substituted furyl, thienyl, substituted thienyl group or cycloalkyl group together with the substituent A; R.sub.4 is hydrogen, alkyl or alkenyl group; and R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 are hydrogen, alkyl or substituted alkyl, respectively,
a non-toxic salt thereof, a process for the preparation of said compound or salt, as well as an antitumor agent comprising as an effective agent at least one of said compound and salt.

REFERENCES:
patent: 3505376 (1970-04-01), Frankel et al.
patent: 4360686 (1977-11-01), Wang et al.
patent: 4434161 (1984-02-01), Barcza
Translation of Zhurnan Obschei Khimii, (vol. 39) (No. 8) pp. 1782-1783, Aug. (1969).

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