Organoselenium compounds with pro-oxidant activity and pharmaceu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514359, 544 1, 548121, C07D29312, C07D29310, C07D42112, A61K 3141

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active

060573104

ABSTRACT:
Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.

REFERENCES:
Emerit, I. (1994) Free Radic. Biol. Med. 16:99-109.
Blasig et al. (1994) Free Radic. Biol. Med. 16:35-41.
Walton et al. (1992) Int. J. Radiat. Oncol. Biol. Phys. 22:643-7.
Chaudiere et al. (1992) Arch. Biochem. Biophys. 296:328-36.
Said et al. (1989) Ann. Rev. Resp. Dis.139:1553-64.
Sinha et al. (1987) Biochem. 26:3776-81.
Smith, L.L. (1986) Ann. Rev. Physiol. 48:681-92.
Doroshow, J.H. (1986) P.N.A.S. 83:4514-8.
Troll et al. (1985) Ann. Rev. Pharmocol. Toxicol. 25:509-28.
Ames, B.N. (1983) Science 221:1256-64.
Umezama, H. (1979) In: Bleomycin: chemical, biochemical and biological aspects. Hecht, S.M. ed., Spring Verlag, NY, p.24-36.
Dische et al. (1979) Int. J. Radiat. Oncol. Biol. Phys. 5:851-60.
Christian Lambert et al. (1991) Tetrahedron. 47:9053-60.

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