Organophosphoric derivatives useful as anti-parasitic agents

Details Organophosphoric derivatives useful as anti-parasitic agents Organophosphoric derivatives useful as anti-parasitic agents

2006-12-22

2009-12-29

Henley, III, Raymond J (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

Reexamination Certificate

active

07638505

ABSTRACT:
The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4alkoxy, C1-4alkyl, hydroxy, formyl, trifluoromethoxy, phenyl, heterocyclic, heterocyclic-substituted methyl, aminomethyl, hydroxy methyl, bromomethyl, sulfonyl chloride, acetyl chloride, nitroso and cyano, (b) R1is selected from the group consisting of hydrogen, C1-7alkyl, C3-10cycloalkyl, aryl, arylalkyl and heterocyclic, and (c) R2is selected from the group consisting of hydroxy and hydroxy-protecting groups, and stereoisomer, solvates and salts thereof. These compounds are useful as anti-infectious and anti-parasitic agents, in particular anti-malaria agents.

REFERENCES:
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