Organic silicon contrast agents and methods of use

Details Organic silicon contrast agents and methods of use Organic silicon contrast agents and methods of use

1993-08-06

1996-06-11

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 514 63, A61B 5055

Patent

active

055253245

ABSTRACT:
This invention is directed to a magnetic resonance imaging composition for imaging of an organ or organ system comprising an organic silicon compound. Preferably, the organ system is the gastrointestinal tract. The present invention is further directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of an organic silicon compound suspended or dispersed in a physiologically tolerable carrier and generating a magnetic resonance image of said mammal. In a preferred embodiment, the organic silicon compound is a silane. In another preferred embodiment, the organic silicon compound is a siloxane. In yet another preferred embodiment, the organic silicon compound is a polysiloxane.

REFERENCES:
patent: 4804529 (1989-02-01), Bardy et al.
patent: 4951675 (1990-08-01), Groman et al.
patent: 5171755 (1992-12-01), Kaufman et al.

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