Organic salts of β-alanine

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Reexamination Certificate

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Reexamination Certificate

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07956218

ABSTRACT:
The present invention relates to stable salts of β-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.

REFERENCES:
patent: WO 2007/073398 (2007-06-01), None
Berge et al. Journal of Pharmaceutical Sciences, 1977, 66, No. 1, p. 1-19.
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Febbraio Ma, et al. Skeletal muscle energy metabolism during prolonged, fatiguing exercise. J Appl Physiol. Dec. 1999; 87(6):2341-7.
Bate-Smith EC. The buffering of muscle in rigour: protein, phosphate, and carnosine. J Physiol. 1938;92:336-43.
Fitzgerald, M.A., et al., “Some Organic Salts of Glycine, the Alanines and dl-Leucine” Proceedings and Transaction of the Royal Society of Canada (1937), 31, III, 153-157.
Rajagopal, K., et al., “β-Alaninium trichloraceteate at 105K” Acta Crystallographica (2003), E59, 206-208.
Nishijo, J., et al., “The Solid Complex of Aminomalonic Acid with β-Alanine and its Thermal Decomposition” Bulletin of the Chemical Society of Japan, vol. 45, 2070-2074 (1972).
Rajagopal, K., et al., “β-Alaninium meleate” Acta Crystallographica (2001), E57, 922-924.
Krishnakumar, R.V., et al., “β-Alaninium oxalate hemihydrate”, Acta Crystallographica (2002), E58, 117-119.
International Search Report for PCT/CA2007/002264.

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