Organic radiographic contrasting agents for medical devices

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – X-ray contrast imaging agent

Reexamination Certificate

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Details

C424S009400

Reexamination Certificate

active

07407647

ABSTRACT:
The present invention discloses an organic radiographic contrasting agent containing an aliphatic or alicyclic backbone and multiple halogen-substituted aromatic groups. Each of the halogen-substituted aromatic groups in the radiographic contrasting agent is substituted with at least three halogen atoms and is covalently attached to the aliphatic or alicyclic backbone. The present invention also discloses a radio-opaque polymeric material comprising the radiographic contrasting agent and at least one polymer. The radiographic contrasting agent is physically admixed with the at least one polymer or physically embedded or dispersed in the at least one polymer. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.

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Wang J. S. et al.: “In vitro and in vivo biological responses to a novel radiopacifying agent for bone cement” J. Roy. Soc. Interface, vol. 2, No. 2, Mar. 2005, pp. 71-78 XP002461899.
Kjellson F. et al.: “Tensile properties of a bone cement containing non-ionic contrast media” Journal of Material Science, vol. 12, No. 10-12, 2001, pp. 889-894 XP009013837.

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