Organic polymer reagents for solid phase synthesis of oligonucle

Details Organic polymer reagents for solid phase synthesis of oligonucle Organic polymer reagents for solid phase synthesis of oligonucle

1995-03-22

1998-03-03

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2531, 536 2532, 536 2533, 536 2534, 526320, C07H 2100, C08F 1800

Patent

active

057235996

ABSTRACT:
Polymeric reagents useful in the solid phase synthesis of oligomers are provided. These polymeric reagents are suitably loaded with nucleosidyl moieties and do not undergo non-specific chain elongation.

REFERENCES:
patent: 3494904 (1970-02-01), Waples
patent: 3660359 (1972-05-01), Labana
patent: 4070348 (1978-01-01), Kraemer et al.
patent: 4076921 (1978-02-01), Stol et al.
patent: 4138383 (1979-02-01), Rembaum et al.
patent: 4552812 (1985-11-01), Marg et al.
Ikehara et al. eds., "The Synthesis of Polynucleotides," Adv. Carbohydrate Chem. and Biochem., 36, 135-213 (1979); pp. 135, 204-213 supplied.
Caruthers, "DNA Synthesis for Nonchemists: The Phosphoramidite Method on Silica Supports," Ch. 3 in Synthesis and Applications of DNA and RNA, Narang ed., Academic Press, 1987, New York, pp. 47-94; pp. 47 and 52-55 supplied.

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