Organic diamine therapeutic compositions and methods

Details Organic diamine therapeutic compositions and methods Organic diamine therapeutic compositions and methods

1978-10-18

1980-09-02

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546187, 546194, 424244, 546205, 546208, 424246, 546213, 546214, 42424856, 546229, 546230, 424274, 546232, 544 59, 424258, 544 60, 544124, 424275, 544129, 544128, 424285, 544141, 544146, 424263, 544143, 544152, 2605709, 544 62, 549 39, 2605705P, 549 74, 549 75, 260563P, 2603477, 260326, 26032662, 2603265C, 2603265G, 2603265L, 2603265M, 26032685, 2603265D, 26032682, 260239B, 26032681, 546148, 546149, 546191, 546266, 546256, 546255, 546281, 546284, 546283, 546300, A61K 31445, C07D40110

Patent

active

042206502

ABSTRACT:
A series of organic diamine base compounds derived from either an aromatic, alicyclic or heterocyclic ring and possessing, for the most part, an intervening methylene group between the ring and the aforesaid basic moiety have been prepared, including their pharmaceutically acceptable acid addition salts as well as oral pharmaceutical compositions containing same. These particular compounds are found to be useful in therapy as oral hypoglycemic agents. Preferred member compounds include 1,1'-[1,2-phenylenebis(methylene)]bispiperidine, 2,3-dihydro-2-[2-(1-piperidinomethyl)phenylmethyl]-1H-isoindole and 2,3-dihydro-2-[2-(4-morpholinomethyl)phenylmethyl]-1H-isoindole. Alternate methods of preparation are provided and the two principal synthetic routes leading to these compounds are described in some detail.

REFERENCES:
patent: 3510492 (1970-05-01), Szmuszkovicz
patent: 3510493 (1970-05-01), Rynbrandt
patent: 3647804 (1972-03-01), Rynbrandt et al.

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