Organic compounds and their use as pharmaceuticals

Details Organic compounds and their use as pharmaceuticals Organic compounds and their use as pharmaceuticals

1988-04-11

1990-02-27

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514317, 514324, 514326, 514383, 514385, 514397, 514402, 514406, 514443, 514445, 540466, 540480, 546202, 546210, 546211, 546212, 546213, 548255, 548262, 548336, 548374, A61K 3138, C07D33362

Patent

active

049046861

ABSTRACT:
Compounds of the following formula have pharmacutical properties: ##STR1## in which R.sup.1 and R.sup.2 independently are hydrogen, halo, nitro, amino, C.sub.2-5 acylamino, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, N-substituted heterocyclyl, optionally substituted phenyl, optionally substituted phenylthio, optionally substituted phenylsulphonyl or optionally substituted phenylsulphonamido, or R.sup.1 and R.sup.2 together form a C.sub.3-5 alkylene bridge, R.sup.3 is C.sub.1-4 alkyl or C.sub.2-4 alkenyl, and X is (i) --(CH.sub.2).sub.n N(R.sup.4).sub.2 where each R.sup.4 independently is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or optionally substituted C.sub.6 H.sub.5 CH.sub.2 --, and n is 1, 2 or 3, or (ii) a 5- to 8-membered alicyclic group containing one or two nitrogen atoms and directly attached to the amido nitrogen or attached by a C.sub.1-3 alkylene chain; and salts thereof.

REFERENCES:
patent: 3177252 (1965-04-01), Thominet
patent: 3342826 (1967-09-01), Miller et al.
patent: 3932503 (1976-01-01), Weber et al.
patent: 4123550 (1978-10-01), Untch et al.
patent: 4221815 (1980-09-01), Weyer et al.
patent: 4321378 (1982-03-01), Dostert et al.
patent: 4560751 (1985-12-01), Seybold
C.A. 72, 3226a (1970).
C.A. 67, 2167w (1967).
C.A. 101, 122562j (1984).
C.A. 100, 84964m (1984).
Consiglio et al., J. Chem. Soc. Perkin Trans. II, 1983, 1559-61.

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