Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1975-03-28
1977-04-12
Drezin, Norman A.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
A61K 3170
Patent
active
040176061
ABSTRACT:
Novel hydrogenated pyrimidine nucleosides and nucleotides are produced by catalytic hydrogenation, particularly in the presence of a rhodium catalyst. The novel compounds are specifically used to inhibit deaminating enzymes, which would inactivate cytosine arabinoside by conversion to uridine arabinoside. Cytosine arabinoside is used for its anti-viral, particularly anti-herpes and anticytotoxic activity in mammals and birds, as well as to destroy phages which interfere with the production of antibiotics. Novel formulations containing cytosine arabinoside and the hydrogenated pyrimidine nucleosides are advantageous to provide prolonged cytosine arabinoside effects.
REFERENCES:
patent: 3328388 (1967-06-01), Shen et al.
patent: 3444294 (1969-05-01), Hunter
patent: 3462416 (1969-08-01), Hanze et al.
Michelson, The Chemistry of Nucleosides and Nucleotides, (1963) Academic Press, N.Y., N.Y., pp. 27-29.
Camiener Gerald W.
Hanze Arthur R.
Barancik Martin B.
Drezin Norman A.
Saliwanchik Roman
The Upjohn Company
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