Organic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S300000, C514S412000, C514S421000, C540S521000, C540S523000, C540S593000, C546S113000, C548S453000

Reexamination Certificate

active

07419975

ABSTRACT:
Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I

REFERENCES:
patent: 2006/0167066 (2006-07-01), Cohen et al.
patent: WO 01/90070 (2001-05-01), None
patent: WO 2004/005248 (2004-01-01), None
Stables, et al. “GR138676, A Novel Peptidic Tachykinin Antagonist Which is Potent at NK3 Receptors”, Neuropeptides (1994) 27, 333-41.
Deal, et al. “Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists”, J. Med. Chem. (1992) 35, 4195-4204.
Christina R. Arnt, Mihnea V. Chiorean, Michael P. Heldebrant, Gregory J. Gores, and Scott H. Kaufmann, “Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ”. Journal of Biological Chemistry. 2002, vol. 277, No. 46, Nov. 15, 2002, pp. 44236-44243. JBC Papers in Press.
Rachael A. Kipp, Martin A. Case, Aislyn D. Wist, Catherine M. Cresson, Maria Carrell, Erin Griner, Arun Wiita. Phillip A. Albiniak, Jijie Chai, Yigong Shi, Martin F. Semmelhack, and George L. McLendon. “Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners”. Biochemistry. 2002, vol. 41, pp. 7344-7349. American Chemical Society.
Jia-Wei Wu, Amy E. Cocina, Jijie Chai, Bruce A. Hay, and Yigong Shi. “Structural Analysis of a Functional DIAP1 Fragment Bound to Grim and Hid Peptides”. Molecular Cell. 2001; vol. 8, No. 1, pp. 95-104. Cell Press.
Martyn J. Deal, Russell M. Hagan, Simon J. Ireland, Christopher C. Jordan, Andrew B. McElroy, Barry Porter, Barry C. Ross, Michaela Stephens-Smith, and Peter Ward. “Conformationally Constrained Tachykinin Analogues: Potent and Highly Selective Neurokinin NK-2 Receptor Agonists”. Journal of Medicinal Chemistry. 1992; vol. 35, pp. 4195-4204 American Chemical Society.
J. M. Stables, I. J. M. Beresford, S. Arkinstall, S. J. Ireland, D. M. Walsh, P. W. Seale, P. Ward, and R. M. Hagan. “GR138676, A Novel Peptidic Tachykinin Antagonist Which is Potent at NK3 Receptors”. Neuropeptides. 1994; vol. 27, pp. 333-341. Longman Group Ltd.

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