Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-22
2011-03-22
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S479000, C548S547000, C562S505000
Reexamination Certificate
active
07910745
ABSTRACT:
It is intended to provide a labeling precursor compound used for selectively producing radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acids, and to provide a process for producing a radioactive halogen-substituted syn-1-amino-3-cyclobutane-carboxylic acid using the labeling precursor compound. A labeling precursor is used in which a phthalimide group is used as a protective group for protecting the amino group. The syn-form of the radioactive halogen-substituted 1-amino-3-cyclobutane-carboxylic acid can be selectively produced by labeling the labeling precursor with a radioactive halogen followed by deprotecting.
REFERENCES:
patent: 5808146 (1998-09-01), Goodman
patent: 5817776 (1998-10-01), Goodman
patent: 2000-500442 (2000-01-01), None
patent: WO97/17092 (1997-05-01), None
patent: WO-2004/056725 (2004-07-01), None
Greene et al. Protective Groups in Organic Synthesis, Chap. 7, 3rded. Published Online Apr. 23, 2002.
McConathy et al. “Improved synthesis of anti-[18-F]FACBC: improved preparation of labeling precursor and automated radiosynthesis.” Applied Radiation and Isotopes, 58 (2003) pp. 657-666.
Ren. “Reactions for Medicine Synthesis.” Chemical Industry Press, 1stEd. (1988), p. 149.
Shoup and Goodman. J. Labelled Cpd. Radiopharm. 42, 215-224 (1999).
McConathy, Improved synthesis of anti[19F]FACBC: improved preparation of labeling precursor and automated radiosynthesis, Applied Radiation and Isotopes, 58(6):657-666 (2003).
Shoup et al, Synthesis of [F—18]—1-3-fluorocyclobutane-1-cargboxylic acid (FACBC): a PET tracer for tumor delineation, Journal of Labelled Compounds & Radiopharmaceuticals, 42(3):215-225 (1999).
English translation of Chinese Official Action issue don Feb. 5, 2010 in Chinese Application No. 200680017927.X.
REN “Ractions for Medicine Synthesis”. Chemical Press, First Edition (1988), p. 149.
PCT International Preliminary Report on Patentability in PCT/JP2006/309643, dated Nov. 23, 2007.
PCT Written Opinion of the International Searching Authority in PCT/JP2006/309643, dated Nov. 23, 2007.
Office Action dated Oct. 1, 2010, in Russian application 200812677.
Laurent Martarelli, et al., Synthesis ofsyn- andanti-1 -Amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic Acid (FMACBC), Potential PET Ligands for Tumor Detection, Journal of Medical Chemistry, Apr. 26, 2002, pp. 2250-2259, vol. 45, No. 11, American Chemical Society.
Office Action dated Nov. 15, 2010 in Chinese application 200680017927.X , in Chinese accompanied by English language translation.
Hayashi Akio
Ito Osamu
Kurosaki Fumie
Toyama Masahito
Anderson Rebecca L
Fitch Even Tabin & Flannery
Nihon Medi+Physics Co., Ltd.
Otton Alicia L
LandOfFree
Organic compound and method for producing radioactive... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Organic compound and method for producing radioactive..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Organic compound and method for producing radioactive... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2662711