Organic complex of platinum, its preparation and its use for tre

Details Organic complex of platinum, its preparation and its use for tre Organic complex of platinum, its preparation and its use for tre

1981-04-27

1984-06-05

Sneed, Helen M. S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Bacterium or component thereof or substance produced by said...

260429R, C07F 1500, A01N 5502, A61K 3128

Patent

active

044528124

ABSTRACT:
An organic complex of platinum, cis-isocitrato (1,2 diaminocyclohexane) platinum (II) having improved anti-tumor activity and water-solubility. The complex is prepared by reacting cis-dichloro (1,2-diaminocyclohexane) platinum (II) with silver nitrate, removing the silver chloride formed, and reacting the resulting liquid with trisodium isocitrate. The complex is administered in the form of a pharmaceutical composition.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4203912 (1980-05-01), Hydes et al.
patent: 4225529 (1980-09-01), Hydes et al.
patent: 4228090 (1980-10-01), Hydes et al.
Cleare, Coordination Chemistry Revues, 12, pp. 349-360 (1974).
Leh et al., J. of Pharmaceutical Sciences, V65, No. 3, pp. 318 & 319 (1976).

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