Organic acids as catalysts for the erosion of polymers

Details Organic acids as catalysts for the erosion of polymers Organic acids as catalysts for the erosion of polymers

1987-04-03

1988-10-25

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424405, 424409, 424422, 424482, 424486, 424 78, 523124, 523125, 523126, 523127, A61K 3119, A61K 3120

Patent

active

047803193

ABSTRACT:
The invention relates to the use of carboxylic acids incorporated as a catalyst in poly(orthoester)s and other acid labile polymers such that upon exposure to aqueous environments the acid catalyzes the erosion of the polymer matrix. The rate of release of a drug substance incorporated into or surrounded by the poly(orthoester) or other acid labile polymer can be controlled in that the drug is released as the polymer is eroded in response to the catalytic action of the acid incorporated therein.

REFERENCES:
patent: 3383283 (1968-05-01), Brindamour
patent: 3825626 (1974-07-01), McGaugh
patent: 4056665 (1977-11-01), Taylor et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4304767 (1981-12-01), Heller et al.
patent: 4374938 (1983-02-01), Verhelst et al.
patent: 4489056 (1984-12-01), Himmelstein et al.

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