Organ storage solution

Details Organ storage solution Organ storage solution

1998-02-17

2000-05-09

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

435 11, 435 12, 435 13, 435 2, A01N 102

Patent

active

060602325

ABSTRACT:
The invention relates to a solution for storing organs, preferably kidneys. To effectively prevent organ damage, the solution has a high sulfate content and a low chloride content. In particular, the solution comprises about Na.sup.+ (2-30 mM), K.sup.+ (70-130 mM), MgH(30-40 mM), Ce.sup.- (2-20 mM), SO.sub.4.sup.2- (80-95 mM) and raffinose (20-60 mM) at aph of about 7.4.

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Marsh et al., "Hypothermic preservation of hepatocytes. I. Role of cell swelling", Cryobiology 26 (6) : 524-34 (1989).
Abaas, "Induction of aggregation in Streptococcus-mitis by cerain ions", Acta Pathol. Micorbiol. Immunol. Scand. Sect. B Microbiol. 92 (5) : 253-260 (1984).
Nakae S., "Preservation of the Normothermic, Anoxic Canine Heart, Lung, Kidney with Metabolic Inhibitor", Kyorin Igakki Zasshi 9(4):235-40 (1978) Abstract Only.

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