Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Phosphorus or phosphorus compound
Patent
1989-04-28
1990-07-03
Sham, Mukund J.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Phosphorus or phosphorus compound
424679, 424680, 514 2, 514 61, 514 53, 514723, A61H 3108, A61H 3342, A61H 31765, A61H 3702
Patent
active
049389610
ABSTRACT:
An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, in aqueous solution, at least about 3% by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.
REFERENCES:
patent: 3450502 (1969-06-01), Hymes
Chambers et al., Cardiovascular Res., 1989 23(4) 351-8 Chemical Age vol. 110, 1989, Abstract 225260.
Mees, N., Southard, J. and Belzer, F., Inhibition of Ischemic Induced Cellular Swelling in Kidney Cortex Tissue by Lactobionate Anions, J. Trauma, vol 22, No. 2, Feb. 1982, pp. 118-120.
Southard, J. and Belzer, F., Control of Canine Kidney Cortex Slice Volume and Ion Distribution at Hypothermia by Impermeable Anions, Cryobiology 17, 540-548 (1980).
Wahlberg, J., Southard, J., and Belzer, F., Development of a Cold Storage Solution for Pancreas Preservation, Cryobiology 23, 477-482 (1986).
Wahlberg, J., Love, R., Landegaard, L., Southard, J., and Belzer, F., 72-Hour Preservation of the Canine Pancreas, Transplantation 43, 5-8 (1987).
Ploeg, R., Coossens, D., McAnulty, J., Southard, J., and Belzer, F., Successful 72-Hour Cold Storage of Dog Kidneys with UW Solution, Transplantation 46, 191-196 (1988).
Jamieson, N., et al., Preservation of the Canine Liver for 24-48 Hours Using Simple Cold Storage with UW Solution, Transplantation 46, 517-522 (1988).
Jamieson, N., et al., An Analysis of the Components in UW Solution Using the Isolated Perfused Rabbit Liver, Transplantation 46, 512-516 (1988).
Collins, G., et al., Beneficial Effect of Low Concentrations of Cryoprotective Agents on Short-Term Rabbit Kidney Perfusion, Cryobiology 21, 246-249 (1984).
Bennett, J., et al., The Effects of Oxygen Free Radicals on the Preserved Kidney, Cryobiology 24, 264-269 (1987).
Martin D., et al., Experimental Renal Preservation, U. Urology 103, 681-685 (1970).
Hermann, T., et al., Preservation of Canine Kidneys by Hypothermia and Low Flow Perfusion with Bloodless Perfusate, Arch. Surg. 98, 127--127 (1969).
Calne, R., et al., Trickle Perfusion for Organ Preservation, Nature, 235, 171-174 (1972).
Suzuki, S., et al., Twenty-four Hour Preservation of canine Hearts by Retrograde Coronary Sinus Perfusion, J. Heart Transplantation, IV, 76-80 (1984).
Wicomb, W., et al., Ex Vivo Function Evaluation of Pig Hearts Subjected to 24 Hours' Preservation by Hypothermic Perfusion, S. Afr. Med. J. 60, 245-248 (1981).
Belzer, F., et al., Principles of Solid-Organ Preservation by Cold Storage, Transplantation 45, 673-676 (1988).
Daniel, M., Factors Influencing the Survival of Cell Monolayers During Storage at 4.degree., Br. J. exp. Path. 57, 137-147 (1976).
Ganote, C., et al., Cellular Swelling and Irreversible Myocardial Injury, Am. J. Path. 88, 95-118 (1977).
Collins Geoffrey
Wicomb Winston
Bauman Mary P.
Haller James R.
Kaihoi Gregory P.
Sham Mukund J.
Ward E. C.
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