Organ preservation composition comprising nicaraven and methods

Details Organ preservation composition comprising nicaraven and methods Organ preservation composition comprising nicaraven and methods

1997-11-24

2000-02-29

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Differentiated tissue or organ other than blood, per se, or...

435 12, 514340, A01N 102, A01N 4340

Patent

active

060307668

ABSTRACT:
An organ preservative or protective that are characterized by containing (.+-.)-N,N'-propylenedinicotinamide as an active ingredient. The compound not only exhibits outstanding organ preserving and protecting effects: it is also free from any significant problems with side effects and safety aspects. Hence, it is very useful as an organ preservative and protective.

REFERENCES:
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Y. Mori et al, Experimental Studies on Nicaraven as radioprotector. Free radical Scavenging Effect and the Inhibition of Cellular Injury, Chemical Abstracts, vol. 53 No. 6, pp. 704-712, 1993.
Derwent Publications Ltd., Drug for Treating Ischaemic Heart Disease Contains Propylene DI Nicotinamide which Increases Rate of Myocardium Contraction and Lactic Acid Ingestion, Dec. 10, 1991. *Abstract*--JP 3-279328.
T. Koide, Role of Peroxides in the Cerebral Transombrane Ion Fluxes and their Relevance to Ischemic Brain Edema, Chemical Abstracts, vol. 18 No. 1-3, pp. 307-324, 1987.
Derwent Publications, Hydroxy Radical Scavenger Nicotinamide Nitrate for Treatment of Tumor Inflammation, Peptic Ulcer, Senility, Liver Dysfunction, Apr. 26, 1991. *Abstract* JP 3-101621.
T. Asano et al, Amelioration of Ischemic Cerebral Edema by a Free Radical Scavenger, Chemical Abstract, vol. 6 No. 4, pp. 163-168, 1984.
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