Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1996-03-29
2000-12-05
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424474, 424482, A61K 958, A61K 932
Patent
active
061563404
ABSTRACT:
A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeability to water. The second coating layer is directly adjacent to the first coating, and is more permeable to water than the first layer. A method for using this drug in the treatment of a patient is also disclosed.
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patent: 5472714 (1995-12-01), Bourquin
patent: 5541170 (1996-07-01), Rhodes et al.
Hirotani, Y. et al., "Preparation of Controlled-release Granules of Sodium Diclofenac", Chem. Pharm. Bull., vol. 35, pp. 3049-3053 (1987).
Sagara, K. et al., "Bioavailability Study of Commercial Sustained-release Preparations of Diclofenac Sodium in Gastro-intestinal Physiology Regulated-dogs", Chem. Pharm. Bull., vol. 40, pp. 3033-3306 (1992).
Ichikawa, H. et al., "Coating of Pharmaceutical Powders by fluidized Bed Process", Chem. Pharm. Bull., vol. 42, pp. 1308-1314 (1994).
Gupta, V. K. et al., "Controlled Release Microspheres of Diclofenac Sodium Prepared by Spherical Crystallization Technique", Pharmazie, vol. 49, pp. 692-693 (1994).
Guterres, S. S. et al., "Poly(DL-lactide) Nanocapsules Containing Diclofenac: I. Formation and Stability Study", Int. J. Pharm., vol. 113, pp. 57-63 (1995).
Adeyeye Christianah Moji
Fukumori Yoshinobu
Ichikawa Hideki
Bawa Raj
Duquesne University of the Holy Ghost
Meyers Diane R.
Silverman Arnold B.
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