Orally administered pharmaceutical agent for iron and magnesium

Details Orally administered pharmaceutical agent for iron and magnesium Orally administered pharmaceutical agent for iron and magnesium

1989-03-15

1992-09-01

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

424648, 424663, 424665, 514502, 514566, A61K 3326, A61K 3314, A61K 31295, A61K 31205

Patent

active

051437325

ABSTRACT:
An orally administered pharmaceutical agent that is particularly suited for iron and magnesium substitutive therapy is disclosed. This drug consists of a combination of one or more pharmaceutically and physiologically compatible iron compounds, one or more pharmaceutically and physiologically compatible magnesium compounds, and, if the magnesium compounds do not contain any chlorine atoms dissociable in aqueous media and saturating the available magnesium valences, the drug further consists of one or more pharmaceutically and physiologically compatible compounds providing chlorine ions in aqueous media. The iron compounds, magnesium compounds and chlorine ion supplying compounds may be mixed with the conventional pharmaceutical solvents and/or thinners and/or auxiliary matter. Unexpectedly, this drug makes it possible to simultaneously administer magnesium or calcium compounds with iron compounds, without thereby causing reduced iron resorption.

REFERENCES:
patent: 4751085 (1988-06-01), Gaull
"The Pharmacological Basis of Therapeutics," Goodman and Gilman, Pergamon ess, New York, N.Y., pp. 1286 and 907 (1990).
"Magnesium Supplementation in Pregnancy," Spatling et al., Brit. J. Obstet. Gyn. 95:120-25 (Feb. 1988).
"Is Milk of Magnesia a Potentially Effective Antidote . . . ", Chadwick and Corby, Vet. Hum. Toxicol. (1982), pp. 187-188.
"Effect of Orally Administered Magnesium Hydroxide . . . ", Corby et al., Clin. Toxicol. 23(768):489-99 (1985-1986).
"Inhibition of Iron Absorption by Magnesium Trisilicate," Hall et al., Med. J. Australia (Jul. 12, 1969), pp. 95-96.
"Magnesium Carbonate," Leming et al., Ann. Int. Med., vol. 94(5):660 (May 1981).
"Effect of a Heal of Iron Absorption . . . ", Seligman et al., Blood 64 (Supp.), p. 42a (1984).

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