Orally administerable sustained release pharmaceutical formulati

Details Orally administerable sustained release pharmaceutical formulati Orally administerable sustained release pharmaceutical formulati

1989-09-14

1992-05-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424484, A61K 964

Patent

active

051126192

ABSTRACT:
This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.

REFERENCES:
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patent: 3965256 (1976-06-01), Leslie
patent: 4013784 (1977-03-01), Speiser
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patent: 4711782 (1987-12-01), Okada et al.
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C.A., 89, 80177p (1978).
C.A., 91, 27262c (1979).
Product Bulletin, "The Hard Capsule with the Soft Centre", Elanco Products.
Product Bulletin, "Gelucire.RTM.", Gattefosse Corporation (1983).
Francois et al., Pharm. Ind., 44(1), 86-89 (1982).
Hunter et al., Pharm. Ind., 44(1), 90-91 (1982).
Hunter et al., Pharm. Ind., 45(4), 433-434 (1983).
C.A., 101, 43519x (1984).
C.A., 100, 126920b (1984).

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