Orally administerable sustained release pharmaceutical formulati

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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424457, A61K 964

Patent

active

048470929

ABSTRACT:
This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.

REFERENCES:
Chemical Abstracts, vol. 89: 80177 "Effect of Hydrophilization of Hydrophobic on Release Rate for Capsule", Terk, C. F. et al. J. Phar. Science 1978 67 (7), 935-9.
Chemical Abstracts, vol. 91, 1979: 27262c "in vitro and in vivo Availability of Hydrophilized Phentoine from Capsule", Terk, C. F. et al. J. Phar. Sci. 1979, 68 (5) 634-8.
Product Bulletin, "The Hard Capsule with the Soft Centre", Elanco Products.
Product Bulletin, "Gelucire.RTM.", Gattefosse Corporation (1983).
Francois et al., Pharm. Ind, 44, 1, 86-89 (1982).
Hunter et al., Pharm. Ind., 44, 1, 90-91 (1982).
Hunter et al., Pharm. Ind. 45, 4, 433-434 (1983).

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