Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1989-02-24
1991-01-08
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424455, A61K 950
Patent
active
049834029
ABSTRACT:
Atrial naturiuretic factor (ANF) is encapsulated within hollow acidic proteinoid microspheres which are stable and protective in the acidic stomach of a mammal but which dissolve at the near neutral pH of the blood. Microspheres having diameters of less than about 10 microns readily penetrate the gastrointestinal mucosa and release the ANF in the bloodstream in physiologically active form. Such gastric administration significantly extends the period of effectiveness of ANF as a diuretic and blood pressure suppressant.
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Page Thurman K.
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