Orally active nonaddicting analgesics

Details Orally active nonaddicting analgesics Orally active nonaddicting analgesics

1986-03-24

1988-06-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 44, 546 45, A61K 31485, C07D48902

Patent

active

047497068

ABSTRACT:
Stereoisomerically pure forms of normorphine analogs which have superior analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl-substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent.

REFERENCES:
patent: 4218454 (1980-08-01), DeGraw et al.
patent: 4269843 (1981-05-01), DeGraw et al.
Loew et al., Chemical Abstracts, vol. 87: 127012g, (1977).
Uyeno et al., Chemical Abstracts, vol. 88: 296t, (1978).
DeGraw et al., Chemical Abstracts, vol. 88: 164212p, (1978).
Uyeno et al., Chemical Abstracts, vol. 90: 97480a, (1979).
Jacobson et al., Chemical Abstracts, vol. 98: 27684m, (1983).
Manoharan et al., Chemical Abstracts, vol. 100: 103684p, (1984).
Manoharan et al., Chemical Abstracts, vol. 102: 6882k, (1985).

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