Orally active MIF analogs with an effect on the central nervous

Details Orally active MIF analogs with an effect on the central nervous Orally active MIF analogs with an effect on the central nervous

1979-12-10

1981-07-14

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

042785952

ABSTRACT:
Tripeptide MIF analogs represented by the formula X--D--Leu--Gly--NR.sup.1 R.sup.2 wherein X is Pro or pGlu, and each of R.sup.1 and R.sup.2, when taken separately, is hydrogen or lower alkyl, are useful in the treatment of disorders of the central nervous system.

REFERENCES:
S. Bojusz, et al., Acta Biochem. et. Biophys. Acad. Sci Hung. vol. II (1), pp. 305-309, (1976).
Walker, et al., Science 196, (1977), 85-87.
Pert, et al., Science 194, (1976), 330-332.

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