Orally active LHRH analogs

Details Orally active LHRH analogs Orally active LHRH analogs

1985-10-22

1987-11-10

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514800, 530313, A61K 3743, C07K 720

Patent

active

047057785

ABSTRACT:
Incorporation of a ketomethylene or a hydroxyethylene group in place of the amide linking group between the Pro.sup.9 and Gly.sup.10 residues of LHRH and its analogs improves the oral activity of LHRH or its analogs.

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Ann Clin Res (1978) 10:139, of Coy and Schally.
Tetrahedron Letters (1982) 23,25:2533-2534.
J Med Chem (1980) 23:1392.
LHRH and Its Analogs, Contraceptive and Therapeutic Applications, B. H. Vickery et al, Eds, MTP Press Limited, Lancaster, PA, 1984.

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