Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1985-12-17
1987-10-27
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 58, 514822, 536 21, A61K 31725, A61K 31715, C08B 3710
Patent
active
047030429
ABSTRACT:
The invention provides novel orally active salts of the formula ##STR1## in which .circle. is the skeleton of a polyol, n is the number of OH's in the polyol (3 to 24); p is .gtoreq.3 and .ltoreq.n; r is the available valence of the heparin unit and .gtoreq.3 and .ltoreq.7; sr is equal to pv; and R.sup.+ is ##STR2## in which R.sup.iv is C.sub.1 -C.sub.3 alkyl; R' and R" are C.sub.1 -C.sub.7 alkyl, the same or different, or combined so that --NR'R" represents the residue of a saturated monocyclic secondary amine; R"' is identical to the corresponding portion of a natural amino acid; the alkylene groups contain 1 to 3 carbon atoms; and R.sup.v is H, --CONH.sub.2 or --COO(C.sub.1 -C.sub.7 alkyl). The salts are stable lipoidal "ion pairs" or complexes which can be absorbed through the gastrointestional wall and which slowly release heparinic acid to achieve long-lasting anticoagulant activity. Novel quaternary salts which are intermediates to the heparin salts of the invention are also disclosed.
REFERENCES:
patent: 3506642 (1970-04-01), Koh et al.
patent: 3617344 (1971-11-01), Leininger et al.
patent: 3835112 (1974-09-01), Mardiguian et al.
patent: 3891622 (1975-06-01), Mardiguian et al.
patent: 4020160 (1977-04-01), Bernstein et al.
patent: 4247535 (1981-01-01), Lewis et al.
patent: 4415490 (1983-11-01), Joh
patent: 4510135 (1985-04-01), Teng
Hara et al., . . . Polyelectrolyte Complex of Heparin with . . . Poly(Vinyl Alcohol), Chem. Abstracts 88:121874p (1978).
Baumeister Mary Katherine
Brown J. R.
Rollins Jr. John W.
LandOfFree
Orally active heparin salts containing multivalent cationic unit does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Orally active heparin salts containing multivalent cationic unit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Orally active heparin salts containing multivalent cationic unit will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1272358