Orally active bronchospasmolytic compounds and their preparation

Details Orally active bronchospasmolytic compounds and their preparation Orally active bronchospasmolytic compounds and their preparation

1973-06-21

1976-02-10

Drezin, Norman A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2605706, 424330, A61K 3122, A61K 31135

Patent

active

039378381

ABSTRACT:
Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##EQU1## wherein R.sub.1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R.sub.2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isoproplyamino-ethanol, having the common name isoprenaline.

REFERENCES:
patent: 2460144 (1949-01-01), Moore et al.
patent: 3180887 (1965-04-01), Zolss et al.
patent: 3341594 (1967-09-01), Thoma et al.
patent: 3365496 (1968-01-01), Pear et al.
Zoelss, et al., Chemical Abstracts, Vol. 63, pp. 6895-6896 (1965).
Chemical Abstracts, 61:13242d (1964).
Chemical Abstracts, 59:8655(c) (1963).

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