Orally active bronchospasmolytic compounds

Details Orally active bronchospasmolytic compounds Orally active bronchospasmolytic compounds

1975-07-07

1977-03-08

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2605706, C07C 9326, C07C 9134

Patent

active

040112586

ABSTRACT:
Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##STR1## wherein R.sub.1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R.sub.2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isopropylamino-ethanol, having the common name isoprenaline.

REFERENCES:
patent: 3180887 (1965-04-01), Zolss et al.
Moed et al., Rec. Trav. Chim. Pay Bus. 71, 933 (1952).

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