Orally active antiandrogens

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.

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530330, 530828, C07K 508

Patent

active

049219413

ABSTRACT:
Antiandrogenic peptidyl esters, particularly tri-peptidyl esters, of the active metabolite of flutamide are disclosed.

REFERENCES:
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patent: 4535092 (1986-08-01), Hughes
patent: 4636505 (1987-01-01), Tucker
Peptide Hormones, 1976, pp. 1-7.
Organic Chemistry, Morrison & Boyd, 3rd ed., pp. 1149-1160.
Katchen et al, J. Clin. Endocrin. and Metab., 41 (1975), pp. 373-379.
The Concise Chemical and Technical Dictionary, H. Bennet, ed. (Chemical Publishing Co., Inc., 1974) p. XXIV.
Invest Urol., 10 (1972), pp. 123-130.
Endocrinology, 91 (1972), pp. 427-437.
Abstracts of the 1984 ICAAC, Abstract 315.

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