Oral vaccines

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

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435320, 4351723, 435 693, 424 89, 424 93, C12N 700, C12N 1500, C12P 2100

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active

049202090

ABSTRACT:
Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.

REFERENCES:
Ellman et al., Nucleic Acid Research, vol. 11, pp. 4689-4701, 1983.
Laub et al., J. Virology, vol. 48, pp. 271-280, 1983.
Dyall-Smith et al., vol. 12, pp. 3973-3982, 1984.
Glugman et al., Eukaryobic Viral Vectors, Meeting date 1981, pp. 187-192.

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