Oral vaccine comprising antigen surface-associated with red bloo

Details Oral vaccine comprising antigen surface-associated with red bloo Oral vaccine comprising antigen surface-associated with red bloo

1997-01-06

1999-03-16

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

42419611, 4241941, 4241931, 4242041, 530350, A61K 3912, A61K 39385, C07K 100, C07K 1400

Patent

active

058826491

ABSTRACT:
Red blood cells or derivatives thereof such as ghost preparations, whole cell membrane preparations or fragments thereof, can act as a potent carrier for orally administered antigens. Mucosal immunity in particular can be effectively induced against such viruses as influenza when adsorbed to chicken red blood cells and orally administered.

REFERENCES:
patent: 4157390 (1979-06-01), Parry et al.
patent: 4403037 (1983-09-01), Coates
patent: 4904468 (1990-02-01), Gill et al.
patent: 5075109 (1991-12-01), Tice et al.
patent: 5643577 (1997-07-01), Pang et al.
Chaicumpa, et al. "Oral Vaccine Against Choler . . . " Southeast Asian J. Trop Med Pub Health 18(2):142-148 (Abstract), 1987.
Colwell, et al. (1986) "Method for Generating a High Frequency of Hybridomas Producing Monoclonal IgA Antibodies", Methods of Enzymology 121: 42-51.
Farag-Mahmod, et al. (Jun. 1988) "Immunogenicity and Efficacy of Orally Administered Inactivated Influenza Virus Vaccine in Mice", Vaccine 6:262-268.
Jones, et al. (1988) "Cellular Immune Responses in the Murine Lung to Local Immunization with Influenza A Virus Glycoproteins in Micelles and Immunostimulatory Complexes (Iscoms)", Scand. J. Immunol. 27:645-652.
Kreuter, et al. (Apr. 1981) "Long-Term Studies of Microencapsulated and Adsorbed Influenza Vaccine Nanoparticles", Journal of Pharmaceutical Sciences 70(4):367-371.
Milch, et al. (1988) PNAS 85(5):1610-1614, Abstract.
Mullenhacker, et al. (1988) Immunol. Cell Biol. 66:153-157.
Pang, et al. (Feb. 1992) "A Novel Particulate Influenza Vaccine Induces Long-Term and Broad-Based Immunity in Mice after Oral Immunization", Journal of Virology:1162-1170.
Posnett, et al. (1988) "A Novel Method for Producing Anti-Peptide Antibodies", J. Biol. Chem. 263(4):1719-1725.
Waugh, et al. (1976) "Viscoelastic Properties of Erythrocyte Membranes of Different Vertebrate Animals", Microvasc. Res. 12:291-304, Abstract.
White, et al. (1986) Medical Virology, Academic Press, New York, pp. 509-512.
Derwent Abstract Accession No. 83738B/46, SU,A 649435 (UFA Vaccine Sera), Feb. 28, 1979.
Derwent Abstract Accession No. 55028A/30, SU,A 562064 (Sverd Virus Infect), Oct. 10, 1977.
Derwent Abstract Accession No. 85-089709/15, Class J04, JP,A 60-038645 (Green Cross Corp.), Feb. 28, 1985.

Affiliated with

Also associated with

Rating

Oral vaccine comprising antigen surface-associated with red bloo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oral vaccine comprising antigen surface-associated with red bloo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral vaccine comprising antigen surface-associated with red bloo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-814816