Oral treatment of hemophilia

Details Oral treatment of hemophilia Oral treatment of hemophilia

2007-05-22

2007-05-22

Kaushal, Sumesh (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C435S069100, C435S320100, C435S325000, C435S455000, C800S004000, C800S007000, C800S008000, C800S014000, C800S017000

Reexamination Certificate

active

10485696

ABSTRACT:
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.

REFERENCES:
patent: 4348384 (1982-09-01), Horikoshi et al.
patent: 4873316 (1989-10-01), Meade et al.
patent: 5589604 (1996-12-01), Drohan et al.
patent: 5880327 (1999-03-01), Lubdon et al.
patent: 5948407 (1999-09-01), McGuinness et al.
patent: 6046380 (2000-04-01), Clark
patent: 6221349 (2001-04-01), Couto et al.
patent: 6255554 (2001-07-01), Lubon et al.
patent: 6344596 (2002-02-01), Velander et al.
patent: 0 294 910 (1988-12-01), None
patent: WO 80/01456 (1980-07-01), None
patent: WO 95/27512 (1995-10-01), None
Terada et al, Vox Sang. 80(1):61-62, 2001.
Pasi et al, Lancet. 361(9371):1801-9, 2003.
Clark et al,. “The Molecular Manipulation of Milk Composition,”Genome 31:950-955 (1989).
Hemker et al., “Oral Treatment of Hæmophilia A by Gastrointestinal Absorption of Factor VIII Entrapped in Liposomes,”The Lancet, pp. 70-71, Jan. 12, 1980.
Hennighausen, “Transgenic Factor VIII: The Milky Way and Beyond,”Nature Biotechnol. 15:945-946 (1997).
High, “Gene-Based Approaches to the Treatment of Hemophilia,”Ann. N.Y. Acad. Sci. 961:63-64 (2002).
Kaplan et al., “Factor VIII Inhibitors. Potential for Prevention of Inhibitor Formation by Immune Tolerance,”Semin Thromb Hemost. 26:173-178 (2000).
Kay et al., “Gene Therapy for the Hemophilias,”Proc. Natl. Acad. Sci. USA 96:9973-9975 (1999).
Lindgren et al., “Does Peroral Administration of Factor VIII Induce Oral Tolerance in Patients with Acquired Haemophilia A?,”Throm Haemost 83:632-633 (2000).
Mariani et al., “Immune Tolerance to Factor VIII: The International Registry Data,”Adv. Exp. Med. Biol. 386:201-208 (1995).
Morcöl et al., “The Porcine Mammary Gland as a Bioreactor for Complex Proteins,”Ann. N.Y. Acad. Sci.2:218-233 (1994).
Niemann et al., “Expression of Human Blood Clotting Factor VIII in the Mammary Gland of Transgenic Sheep,”Transgenic Res. 8:237-247 (1999).
Paleyanda et al. “Transgenic Pigs Produce Functional Human Factor VIII in Milk,”Nature Biotechnol. 15:971-975 (1997).
Roberts, “Induction of Immune Tolerance to Factor VIII: A Plea for Caution,”JAMA 259:84-85 (1988).
Udall et al., “Development of Gastrointestinal Mucosal Barrier. I. The Effect of Age on Intestinal Permeability to Macromolecules,”Pediatr. Res. 15:241-244 (1981).
Velander et al., “Transgenic Livestock as Drug Factories,”Sci Am. 276:70-74 (1997).
Warshaw et al., “Intestinal Absorption of Intake Antigenic Protein,”Surgery 76:495-499 (1974).
Wilmut et al., “Modification of Milk Composition,”J. Reprod. Fert. Suppl. 41:135-146 (1990).
Yee et al., “Oral Immune Tolerance Induction to Factor VIII Via Breast Milk, a Possibility?,”Haemophilia 6:591 (2000).

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