Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-08-22
1996-07-23
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4242031, A61K 3902, A61K 3900, A61K 3938
Patent
active
055387292
ABSTRACT:
Method of eliciting in a mammalian host a protective immune response to Helicobacter infection, by orally administering to the host an immunogenically effective amount of Helicobacter antigen. Vaccine compositions are also provided.
REFERENCES:
patent: 5268276 (1993-12-01), Holmgren et al.
patent: 5417986 (1995-05-01), Reid et al.
Newell, D. G.; Journal of General Microbiology (1987), 133 p. 163-170.
Burr et al, Infection & Immunity 56: 99-105, 1988 Mucosal and Systemic Immunity to Campylobacter jejuni in Rabbits after Gastric Inoculation.
McSweegan et al, Infection and Immunity 55: 1431-1435, 1984, Intestinal Mucus Gel and Secretory Antibody Are Barriers to Campylobacter jejuni Adherence to INT 407 Cells.
Rappuoli et al, European J. Gastroenterol. Hepatol 5/Suppl 2: S76-S78, 1993, The Development of a Vaccine Against Helicobacter pylori: A Short Overview. (Abstract).
Elson et al, The Journ. of Immunology, 132: 2736-2741, 1984, Generalized Systemic & Mucosal Immunity in Mice After Mucosal Stimulation with Cholera Toxin.
Von Wulffen FEMS Microb. Letters 42: 129-133, 1987.
Lycke et al, Immunology 59: 301-308 1986, Strong Adjuvant Properties of Cholera Toxin on Gut Mucosal Immune Responses to Orally Presented Antigens.
Fox et al, Infection and Immunity 59: 785-791, 1991, Helicobacter felis: Gastritis in Gnotobiotic Rats: An Animal Model of H. pylori Gastritis.
Heap et al, Microb. Ecol. Health Dis 4: S119, 1991 Immunisation & Gastric Colonisation with Helicobacter felis (Abstract Only) Oct.
Pavlovskis et al Microb Ecol. Health Dis 4: S10, 1991 Oct. Adjuvant Effect of E. coli Heat-labile Enterotoxin on Host Immune Response Following Vaccination with Non-labile Campylobacter Antigens.
Baskerville and Newell, Naturally Occurring Chronic Gastritis and C pylori Infection in the Rhesus Monkey: A Potential Model for Gastritis in Man, Gut 29:465-472, 1988.
Parsonnet et al., VIth Int. Workshop of Campylobacter, Helicobacter, and Related Organisms. Oct. 7-10, 1991.
Blaser, Gastric Campylobacter-like Organisms, Gastritis, and Peptic Ulcer Disease, Gastroenterolgy 93:371-83, 1987.
Bowie et al., Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions, Science 247:1306-1310, 1990.
Burr et al., Mucosal and Systemic Immunity to Campylobacter jejuni in Rabbits after Gastric Inoculation, Infection and Immunity 56:99-105, 1988.
Chamberlain et al., Campylobacter (Helicobacter) pylori Is Peptic Disease a Bacterial Infection? Arch. Intern Med. 150:951-955, 1990.
Chen et al., Lack of Protection Against Gastric Helicobacter Infection Following Immunisation with Jack Bean Urease: The rejection of a Novel Hypothesis, FEMS Microbiology Letters 116:245-250, 1994.
Chen et al., Immunisation Against Gastric Helicobacter Infection in a Mouse/Helicobacter felis Model, The Lancet 339:1120-1121, 1992.
Clayton et al., Molecular Cloning and Expression of Campylobacter pylori Species-Specific Antigens in Escherichia coli K-12, Infection and Immunity 57:623-629, 1989.
Clayton et al., Nucleotide Sequence of Two Genes from Helicobacter pylori Encoding for Urease Subunits, Nucleic Acids Research 18:362, 1990.
Clements et al., Adjuvant Activity of Escherichia coli Heat-labile Enterotoxin and Effect on the Induction of Oral Tolerance in Mice to Unrelated Protein Antigens, Vaccine 6:269-277, 1988.
Coelho et al., Duodenal Ulcer and Eradication of Helicobacter pylori in a Developing Country, Scandinavian J. Gastroenterolgy 27:362-366, 1992.
Crabtree et al., Mucosal Humoral Immune Response to Helicobacter pylori in Patients with Duodenitis, Digestive Diseases and Sciences 36:1266-1273, 1991.
Czinn and Nedrud, Oral Immunization Against Helicobacter pylori, Infection and Immunity 59:2359-2363, 1991.
Czinn and Carr, Rapid Diagnosis of Campylobacter Pyloridis-associated Gastritis, J. Pediatrics 110:569-570, 1987.
Czinn et al., Protection of Germ-free Mice from Infection by Helicobacter felis after Active Oral or Passive IgA Immunization, Vaccine 11:637-642, 1993.
Davin et al., Proceedings of the DDW, American Gastroenterological Association, May 16-19, 1993, 1213, A-304.
Dick-Hegedus and Lee, Use of a Mouse Model to Examine Anti-Helicobacter pylori Agents, Scandinavian Journal of Gastroenterology, 26:909-915, 1991.
Donaldson and Toskes, The Relation of Enteric Bacterial Populations to Gastrointestinal Function and Disease, Gastrointestinal Disease, 3rd Edition, (W. B. Saunders Co., Philadelphia 1983) pp. 44-54.
Drazek et al., Characterization and Presumptive Identification of Helicobacter pylori Isolates from Rhesus Monkeys, J. Clin. Microbiology 32:1799-1804, 1994.
Dubois et al., Natural Gastric Infection with Helicobacter pylori in Monkeys: A Model for Spiral Bacteria Infection in Humans, Gastroenterology 106:1405-1417, 1994.
Dunn et al., Purification and Characterization of Urease from Helicobacter pylori, J. Biol. Chem. 265:9464-9469, 1990.
Eaton et al., Essential Role of Urease in the Pathogenesis of Gastritis Induced by Helicobacter pylori in Gnotobiotic Piglets, Gastroenterology 98:A654, 1990.
Eaton et al., Campylobacter pylori Virulence Factors in Gnotobiotic Piglets, Infection and Immunity 57:1119-1125, 1989.
Eldridge et al., Biodegradable Microspheres: Vaccine Delivery System for Oral Immunization, Current Topics in Microbiology and Immunology 146:59-66, 1989.
Elson and Ealding, Generalized Systemic and Mucosal Immunity in Mice After Mucosal Stimulation with Cholera Toxin, J. Immunology 132:2736-2741, 1984.
Elson et al., A Levage Technique Allowing Repeated Measurement of IgA Antibody in Mouse Intestinal Secretions, J. Immunological Methods 67:101-108, 1984.
Engstrand et al., Inoculation of Barrier-Born Pigs with Helicobacter pylori: a Useful Animal Model for Gastritis Type B, Infection and Immunity 58:1763-1768, 1990.
Evans et al., Characterization of the Helicobacter pylori Urease and Purification of its Subunits, Microbial. Pathogenesis 10:15-26, 1991.
Ferrero and Labigne, Cloning, Expression and Sequencing of Helicobacter felis Urease Genes, Molecular Microbiology 9:323-333, 1993.
Fox et al., Helicobacter felis Gastritis in Gnotobiotic Rats: an Animal Model of Helicobacter pylori Gastritis, Infection and Immunity 59:785-791, 1991.
Fox et al., Campylobacter mustelae, a New Species Resulting from the Elevation of Campylobacter pylori subsp. mustelae to Species Status, International J. Systemic Bacteriology 39:301-303, 1989.
Fox et al., Gastric Colonization by Campylobacter pylori subsp. mustelae in Ferrets, Infection and Immunity 56:2994-2996, 1988.
Fox et al., Helicobacter mustelae-Associated Gastritis in Ferrets, Gastroenterology 99:352-361, 1990.
Fubara and Freter, Protection Against Enteric Bacterial Infection by Secretory IgA Antibodies, J. Immunology 111:395-403, 1973.
Gilligan and Po et al., Oral Vaccines: Design and Delivery, International Journal of Pharmaceutics 75:1-24, 1991.
Goodwin et al., Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as . . . Helicobacter mustelae comb. nov., Respectively, International J. Systematic Bacteriology 39:397-405, 1989.
Gootz et al., Immunological and Molecular Characterization of Helicobacter felis Urease, Infection and Immunity, 62, 793-798, 1994.
Graham, Campylobacter pylori and Peptic Ulcer Disease, Gastroenterology 96:615-25, 1989.
Gupta et al., Adjuvants--a Balance Between Toxicity and Adjuvanticity, Vaccine 11:293-306, 1993.
Guruge et al., Detection of Antibodies to Helicobacter pylori Cell Surface Antigens, Scand. J. Infect. Dis. 22:457-465, 1990.
Handt et al., Helicobacter pylori Isolated from the Domestic Cat: Public Health Implications, Infection and Immunity 62:2367-2374, 1994.
Heap and Lee, Immunisation and Gastric Colonisation with Helicobacter felis, Microb. Ecol. Health Dis. 4:s119; VIth International Workshop on Campylobacter, Helicobacter and Related Organisms, Oct. 7-10, 1991.
Holmgren et al., New Cholera Vaccines, Vaccine 7:94-96, 1989.
Hu and Mobley, Purification and N-Terminal Analysis of Urease from Helicobacter pylori, Infection and Immunity 58:992-998, 1990.
Hu et al., Purification of R
Czinn Steven J.
Nedrud John G.
Housel James C.
OraVax, Inc.
Portner Ginny Allen
LandOfFree
Oral treatment of helicobacter infection does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral treatment of helicobacter infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral treatment of helicobacter infection will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-711333