Oral sustained release pharmaceutical formulation and process

Details Oral sustained release pharmaceutical formulation and process Oral sustained release pharmaceutical formulation and process

1990-07-09

1991-12-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424468, 424469, 424470, 514282, 514 80, 514327, 514165, 514569, 514550, 514330, 514716, 514653, 5147725, A61K 124

Patent

active

050733800

ABSTRACT:
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered smoothness enhancer, e.g. povidone, erosion promoter, e.g. pregelatinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation into a tablet with a smooth outer surface, which tablet provides, upon administration, a slow release of the pharmaceutical active.

REFERENCES:
patent: 4820522 (1989-04-01), Radebaugh

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