Oral sustained release pharmaceutical formulation and process

Details Oral sustained release pharmaceutical formulation and process Oral sustained release pharmaceutical formulation and process

1989-08-11

1991-04-02

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424468, 424469, 424470, 424472, 424486, 424488, 424 80, A61K 922

Patent

active

050046136

ABSTRACT:
A pharmaceutical sustained release tablet or tablet layer is formed by making a wet granulation, using povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with a pharmaceutical active, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promotor, e.g. pregelantinized starch, additional wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the pharmaceutical active.

REFERENCES:
patent: 4264573 (1981-04-01), Powell et al.
patent: 4308251 (1981-12-01), Dunn et al.
patent: 4465660 (1984-08-01), David et al.
patent: 4661521 (1987-04-01), Salpekar
patent: 4753801 (1988-07-01), Oren et al.
patent: 4820522 (1989-04-01), Radebaugh et al.
Z. T. Chowhan and L. Palagyi, "Harness Increases Induced by Partial Moisture Loss in Compressed Tablets and its Effect on in vitro Dissolution", in the Journal of Pharmaceutical Sciences, vol. 60, No. 10, Oct. 1978, pp. 1385-1389.

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