Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1991-09-13
1993-05-25
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424451, 424456, 424457, 424458, 424459, 424461, 424462, 424489, 424494, 424495, 424497, 424499, 514962, 514963, 514964, A61K 954
Patent
active
052138119
ABSTRACT:
Sugar or sugar/starch beads coated with a first coating of a drug, for example 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(4-pyridinyl)-nicotinonitrile (milrinone), hydroxypropyl methylcellulose or hydroxypropyl cellulose and a plasticizer selected from triacetin, diacetylated monoglycerides, glycerin, propylene glycol, polyethylene glycol, diethyl phthalate and triethyl citrate or a mixture of two or more thereof and a second coating of high-viscosity ethylcellulose, low-viscosity ethylcellulose, hydroxypropyl cellulose, polyvinyl acetate phthalate and a plasticizer selected from diacetylated monoglycerides and triacetin or a mixture thereof and optionally coated with additional first coating and capsules filled therewith and method of preparation thereof are disclosed.
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patent: 4540602 (1985-09-01), Motoyama et al.
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patent: 4752470 (1988-06-01), Mehta
patent: 4800084 (1989-01-01), Zerbe
patent: 4806361 (1989-02-01), Harrison et al.
patent: 5026560 (1991-06-01), Makino et al.
Frisbee Steven E.
Lawton Margaret A.
Stetsko Gregg
Balogh Imre
DuPont Paul E.
Harrison Robert H.
Miller Theodore C.
Page Thurman K.
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