Oral sustained release acetaminophen formulation and process

Details Oral sustained release acetaminophen formulation and process Oral sustained release acetaminophen formulation and process

1987-07-27

1989-04-11

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424464, 424470, 424 80, A61K 922

Patent

active

048205222

ABSTRACT:
An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.

REFERENCES:
patent: 4013785 (1977-03-01), Weintraub et al.
patent: 4189469 (1980-02-01), Gleixner et al.
patent: 4369308 (1983-01-01), Trubiano
patent: 4439453 (1984-03-01), Vogel
patent: 4661521 (1987-04-01), Salpekar et al.
patent: 4702918 (1987-10-01), Ushimaru et al.

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