Oral product for controlling gingivitis

Details Oral product for controlling gingivitis Oral product for controlling gingivitis

1984-01-16

1985-04-30

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

424 49, A61K 722, A61K 716

Patent

active

045143820

ABSTRACT:
An oral composition for treating gingivitis and periodontitis comprising an oral vehicle and an effective amount of the water insoluble antigingivitis agent, imidazolyl-1-1-(p-chlorophenoxy) 3-3-dimethyl 2-butanone solubilized in a nonionic compound containing a mixture of hydrophobic and hydrophilic groups of sufficient length to effect solubilization in an aqueous vehicle, in the weight ratio of 1:1 to 25:1 and preferably 3:1 to 25:1 solubilizer:imidazoyl compound, said agent being selectively effective against the gram negative anaerobic micro-organisms associated with periodontitis.

REFERENCES:
patent: 3497591 (1970-02-01), Yankell et al.
patent: 3523154 (1970-08-01), Gould
patent: 3577520 (1971-05-01), Savini
patent: 3812142 (1974-05-01), Meiser et al.
patent: 3903287 (1975-09-01), Meiser et al.
patent: 3911133 (1975-10-01), Edwards
patent: 4029760 (1977-06-01), De Roeck et al.
patent: 4243670 (1981-01-01), Regel et al.
patent: 4272512 (1981-06-01), Gaffar
patent: 4273758 (1981-06-01), Liau
Heijl and Lindhe, J. Clinical Periodontology 6, 197-209, (1979).
Listgarton et al., J. Periodont. Res. 14: 65-75, (1979).
Loesche et al., J. Clinical Periodontology, 8: 29-44, (1981).
Flagyl, Physician Reference Handbook, p. 1761.

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