Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,1

Details Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,1 Oral pharmaceutical preparations containing 9-deoxo-11-deoxy-9,1

1986-07-08

1988-07-05

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

424156, 424157, 424465, 424474, 424489, 424490, 514 29, A61K 928, A61K 922, A61K 926

Patent

active

047553855

ABSTRACT:
There is described a solid pharmaceutical preparation for oral administration which produces high and long-lasting blood and tissue levels, containing 9-deoxo-11-deoxy-9,11-[imino[2-(2-methoxyethoxy)-ethylidene]oxy]-(9S)-eryt hromycin as active substance, in which the active substance must be intimately mixed with a basic excipient in a ratio of 1 mol of active substance to at least 2 gram-equivalents of basic excipient, and the preparations are coated with a gastric juice-resistant lacquer which is soluble in a pH range of between 5.5 and 6.8, and processes for preparing them. The solid pharmaceutical preparations include tablets, pellets or granules and a syrup can be produced from the latter.

REFERENCES:
patent: 3081233 (1963-03-01), Enz et al.
patent: 3784683 (1974-01-01), Prillig et al.
patent: 3865935 (1975-02-01), Amann
patent: 3891755 (1975-06-01), Mehta
patent: 4101651 (1978-07-01), Kobayashi et al.
patent: 4127647 (1978-11-01), Sato et al.
patent: 4289751 (1981-09-01), Windheuser
patent: 4340582 (1982-07-01), Kriesel et al.

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