Oral pharmaceutical preparation containing erythromycin base

Details Oral pharmaceutical preparation containing erythromycin base Oral pharmaceutical preparation containing erythromycin base

1995-06-28

1999-04-27

Levy, Neil S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424471, 514 29, A61K 920

Patent

active

058978771

ABSTRACT:
Basic pellets containing erythromycin base, to which a small amount of a slightly acid salt, such as potassium dihydrogen phosphate and possibly an additive is added for improved release of the active substance in the intestinal tract, are provided with a coating that contains a polymer resistant to gastric juice, such as poly(methacrylic acid, -ethylacrylate), a separating agent, such as talc, and a softening agent, such as diethyl phthalate.

REFERENCES:
patent: 5049394 (1991-09-01), Howard et al.
patent: 5225202 (1993-07-01), Hodges et al.
Charman et al: J. Bone JT. SURG. Serv.A. 1976 5811 (76-B1) Effect of Polymethacrylate & Antibiotic Combinations.

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