Oral pharmaceutical composition with improved bioavailability

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

Reexamination Certificate

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Reexamination Certificate

active

07867517

ABSTRACT:
The present invention relates to prompt-release oral pharmaceutical compositions containing one or more active principles solubilised, suspended or embedded in a suitably formulated amphiphilic matrix for improving in vitro and in vivo bioavailability of medicaments sparingly absorbed through the oral route and/or with problems of high variability of absorption in the gastrointestinal tract.

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patent: 6056944 (2000-05-01), Finidori
patent: 6248363 (2001-06-01), Patel et al.
patent: WO 97/18798 (1997-05-01), None
patent: WO 98/24430 (1998-11-01), None
patent: WO 02/24172 (2002-03-01), None
Elmaleh et al. Probe into the physical properties of gelucire 44/14 pharmaceutical formulation.
Sharma et al, J. Pharm. Sci 1995 Abstract only.
Shah et al, Drug Dev. Ind. Pharm, 1999 25(1) 63-67 Abstract Only.
Rajewski et al. J. Pharm. Scieces 85(11) 1996, 1142-1169.

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