Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1986-06-03
1990-07-10
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424434, 424435, 424436, 424494, 424495, A61K 936, A61F 902
Patent
active
049405870
ABSTRACT:
An arrangement is provided for the application of an oral pharmaceutical to the mucosa of the oral or nasal cavity, for sustained release there of the drug. The arrangement of the invention comprises a body which has a size and shape suitable for insertion into and retention in the oral or nasal cavity, the body being formed of granules of a higher aliphatic alcohol and a hydrated water soluble hydroxyalkyl cellulose having the drug distributed therethrough. This body is coated with a cellulose derivative which is adherent to the mucosa. As a consequence, upon insertion into the oral or nasal cavity, the body adheres to the mucosa and the drug is there slowly released and absorbed into the body. The arrangement is preferably in the form of a buccal tablet, particularly a kidney shaped buccal tablet. Any drug suitable for oral administration can be used, morphine being preferred. The cellulose derivative which is preferred is hydroxypropyl cellulose. The higher aliphatic alcohol is preferably cetostearyl alcohol, and the water soluble cellulose is preferably hydroxyethyl cellulose.
REFERENCES:
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4039653 (1977-08-01), DeFoney et al.
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4695591 (1987-09-01), Hanna et al.
Jenkins Anthony W.
Leslie Stewart T.
Miller Ronald B.
Euroceltique S.A.
Page Thurman K.
LandOfFree
Oral pharmaceutical composition through mucosa does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral pharmaceutical composition through mucosa, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral pharmaceutical composition through mucosa will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1720102