Oral pharmaceutical composition for acid sensitive proteinaceous

Details Oral pharmaceutical composition for acid sensitive proteinaceous Oral pharmaceutical composition for acid sensitive proteinaceous

1989-09-27

1991-07-16

Page, Thurman

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 88, 424 89, 424465, 424474, 424482, 424489, 424494, 424 93, 514888, A61K 948, A61K 3700

Patent

active

050324055

ABSTRACT:
An orally administrable formulation of a biologically active, acid sensitive, proteinaceous agent comprises a composition of a lyophilized mixture of the proteinaceous agent and maltose, optionally with a particulate diluent. This composition is then uniformly coated with an alkaline-soluble polymeric film containing at least one partially esterified polymethacrylic acid as a major component.

REFERENCES:
patent: 3767790 (1973-10-01), Guttag
patent: 3870598 (1975-03-01), Aleseeva et al.
patent: 4102999 (1978-07-01), Umezawa et al.
patent: 4337242 (1982-06-01), Markus et al.
patent: 4397844 (1983-08-01), Baschang et al.
patent: 4710378 (1987-12-01), Ohtomo et al.
patent: 4870059 (1989-09-01), Mitsuhashi et al.

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