Oral osmotic device with hydrogel driving member

Details Oral osmotic device with hydrogel driving member Oral osmotic device with hydrogel driving member

1994-12-09

1999-02-09

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424435, 424472, 424473, 424474, A61K 924

Patent

active

058690964

ABSTRACT:
An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

REFERENCES:
patent: 3054724 (1962-09-01), Roff et al.
patent: 3402240 (1968-09-01), Cain et al.
patent: 3732865 (1973-05-01), Higuchi et al.
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3854480 (1974-12-01), Zaffaroni
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4111202 (1978-09-01), Theeuwes
patent: 4238475 (1980-12-01), Witzel et al.
patent: 4294829 (1981-10-01), Suzuki et al.
patent: 4327725 (1982-05-01), Cortese et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4612008 (1986-09-01), Wong et al.
patent: 4627971 (1986-12-01), Ayer
patent: 4639368 (1987-01-01), Niazi et al.
patent: 4666705 (1987-05-01), DeCrosta et al.
patent: 4713243 (1987-12-01), Schiraldi et al.
patent: 4725440 (1988-02-01), Ridgway et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4765983 (1988-08-01), Takayanagi et al.
patent: 4783337 (1988-11-01), Wong et al.
patent: 4786503 (1988-11-01), Edgren et al.
patent: 4835142 (1989-05-01), Suzuki et al.
patent: 4859467 (1989-08-01), Grodberg et al.
patent: 4863737 (1989-09-01), Stanley et al.
patent: 4871548 (1989-10-01), Edgren et al.
patent: 4892740 (1990-01-01), Takasima et al.
patent: 4946685 (1990-08-01), Edgren et al.
patent: 4983394 (1991-01-01), Hussein et al.
patent: 5013728 (1991-05-01), Grodberg et al.
patent: 5021053 (1991-06-01), Barclay et al.
patent: 5053032 (1991-10-01), Barclay et al.
patent: 5192550 (1993-03-01), Edgren et al.
"Treatment of denture stomatitis by a sustained drug-delivery device: a preliminary study," J. Dent (1988) vol. 16, pp. 219-221. D. J. Lamb and C. W. I. Douglas.
"Candidosis of the Oral Cavity, Recognition and Management," Drugs vol. 36, pp. 633-642 (1988) K. D. Hay.
"Minor Aphthous Oral Ulcerations: A Double-Blind Cross-over Study of Beclomethasone Dipropionate Aerosol Spray", Scot Med J (1989) vol. 34, pp. 531-532.

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