Oral osmotic device with hydrogel driving member

Details Oral osmotic device with hydrogel driving member Oral osmotic device with hydrogel driving member

1994-09-08

1996-11-12

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424434, 424468, 424413, A61K 924

Patent

active

055737765

ABSTRACT:
An osmotic device (10) for delivering an ergot alkaloid into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an ergot alkaloid (14) and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the ergot alkaloid (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the ergot alkaloid (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of ergot alkaloid (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of ergot alkaloid (14) which has been delivered and/or the amount remaining to be delivered.

REFERENCES:
patent: 3054724 (1962-09-01), Roff et al.
patent: 3402240 (1968-09-01), Cain et al.
patent: 3732865 (1973-05-01), Higuchi et al.
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3854480 (1974-12-01), Zaffaroni
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4111202 (1978-09-01), Theeuwes
patent: 4238475 (1980-12-01), Witzel et al.
patent: 4294829 (1981-10-01), Suzuki et al.
patent: 4327725 (1982-05-01), Cortese et al.
patent: 4478822 (1984-10-01), Haslam et al.
patent: 4572832 (1986-02-01), Kigasawa et al.
patent: 4612008 (1986-09-01), Wong et al.
patent: 4627971 (1986-12-01), Ayer
patent: 4639368 (1987-01-01), Niazi et al.
patent: 4666705 (1987-05-01), DeCrosta et al.
patent: 4713243 (1987-12-01), Schiraldi et al.
patent: 4725440 (1988-02-01), Ridgway et al.
patent: 4749575 (1988-06-01), Rotman
patent: 4765983 (1988-08-01), Takayanagi et al.
patent: 4783337 (1988-11-01), Wong et al.
patent: 4786503 (1988-11-01), Edgren et al.
patent: 4835142 (1989-05-01), Suzuki et al.
patent: 4859467 (1989-07-01), Grodberg et al.
patent: 4863737 (1989-09-01), Stanley et al.
patent: 4871548 (1989-10-01), Edgren et al.
patent: 4892740 (1990-01-01), Takasima et al.
patent: 4946685 (1990-08-01), Edgren et al.
patent: 4983394 (1991-01-01), Hussein et al.
patent: 5013728 (1991-05-01), Grodberg
patent: 5021053 (1991-06-01), Barclay et al.
patent: 5053032 (1991-10-01), Barclay et al.
patent: 5192550 (1993-03-01), Edgren et al.
The Merck Index, pp. 528-529, (1983).
"Treatment of denture stomatitis by a sustained drug-delivery device: a preliminary strudy," J. Dent (1988) vol. 16, pp. 219-221. D. J. Lamb and C. W. I. Douglas.
"Candidosis of the Oral Cavity, Recognition and Management," Drugs vol. 36, pp. 633-642 (1988) K. D. Hay.
"Minor Aphthous Oral Ulcerations: A Double-Blind Cross-over Study of Beclomethasone Dipropionate Aerosol Spray", Scot Med J (1989) vol. 34, pp. 531-532.
"Treatment of Radiostomatitis with Salcoat", Gan No Rinsho, (1990), vol. 36, No. 1, pp. 66-90, Ishii, J. et al.

Affiliated with

Also associated with

Rating

Oral osmotic device with hydrogel driving member does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oral osmotic device with hydrogel driving member, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral osmotic device with hydrogel driving member will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-560806