Oral or intranasal vaccines using hydrophobic complexes having p

Details Oral or intranasal vaccines using hydrophobic complexes having p Oral or intranasal vaccines using hydrophobic complexes having p

1996-07-09

1999-11-16

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242491, 4242501, 4242031, 42419711, 4241931, 5361231, A61K 3902

Patent

active

059852844

ABSTRACT:
An immunogenic complex, essentially consisting of neisserial outer membrane protein proteosomes hydrophobically complexed to native purified bacterial lipopolysaccharide and formulated in accordance with the current invention for mucosal delivery such as via the oral or intranasal route is used as a vaccine. Specifically, a vaccine using shigella lipopolysaccharides complexed to proteosomes for such mucosal administration induces IgG and IgA antibodies in sera and in respiratory and intestinal fluids. Furthermore, such antibodies are associated with protection against shigella infection and these vaccines are herein demonstrated to protect against mucosal infection with shigella.

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