Oral once-per-day organic nitrate formulation which does not ind

Details Oral once-per-day organic nitrate formulation which does not ind Oral once-per-day organic nitrate formulation which does not ind

1989-05-05

1992-06-16

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424456, 424458, 424459, 424460, 424461, 424462, 424463, 514929, 514962, 514963, A61K 954

Patent

active

051223848

ABSTRACT:
A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.

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The United States Pharmacopeia, Twenty-First Revision, pp. 1243-1244.
A copy of the Dow Chemical Company article, "Formulating for Controlled Release with METHOCEL.TM. cellulose ethers".

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