Oral morphine multiparticulate formulation

Details Oral morphine multiparticulate formulation Oral morphine multiparticulate formulation

1997-11-25

2000-05-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424464, 424468, 424469, 424471, 424472, 424482, 424484, 424487, A61K 914

Patent

active

060663391

ABSTRACT:
An oral morphine multiparticulate formulation for once-daily administration to a patient, comprising sustained release particles each having a core containing water soluble morphine and an osmotic agent, the core being coated with a rate-controlling polymer coat comprised of ammonio methacrylate copolymers in an amount sufficient to achieve therapeutically effective plasma levels of morphine over at least 24 hours in the patient.

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