Oral microemulsion composition comprising...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from compositeae

Reexamination Certificate

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C424S725000, C514S452000, C514S557000

Reexamination Certificate

active

07485326

ABSTRACT:
A microemulsion composition comprising biphenyldimethyldicarboxylate (BDD) and silybin or a derivative thereof, or a <i>Carduus marianus</i> extract containing silybin and derivatives thereof, as active ingredients; a co-surfactant; a surfactant; and an oil provides a synergistic therapeutic effect for liver diseases due to the complementary work of the two kinds of active ingredients having different working mechanisms without any adverse side effect or an antagonism, and high <i>in vivo</i> bioavailabilities of both of the active ingredients, when orally administered.

REFERENCES:
patent: 6322805 (2001-11-01), Kim et al.
patent: 6428821 (2002-08-01), Woo et al.
patent: 7078064 (2006-07-01), Zabrecky
patent: 1999-39932 (1999-06-01), None
Kim et al. J. Controlled Release. 2001. vol. 70, pp. 149-155.

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